Unique peptide-binding motif for Mamu-B*037:01: an MHC class I allele common to Indian and Chinese rhesus macaques
Identifieur interne : 002093 ( Main/Exploration ); précédent : 002092; suivant : 002094Unique peptide-binding motif for Mamu-B*037:01: an MHC class I allele common to Indian and Chinese rhesus macaques
Auteurs : Natasja G. De Groot [Pays-Bas] ; Corrine M. C. Heijmans [Pays-Bas] ; Arnoud H. De Ru [Pays-Bas] ; Chopie Hassan [Pays-Bas] ; Nel Otting [Pays-Bas] ; Gaby G. M. Doxiadis [Pays-Bas] ; Frits Koning [Pays-Bas] ; Peter A. Van Veelen [Pays-Bas] ; Ronald E. Bontrop [Pays-Bas]Source :
- Immunogenetics [ 0093-7711 ] ; 2013-12-01.
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Abstract
Abstract: Indian and Chinese rhesus macaques are often used in biomedical research. Genetic analyses of the major histocompatibility class I region have revealed that these macaques display a substantial level of polymorphism at Mamu-A and Mamu-B loci, which have been subject to duplication. Only a few Mamu class I allotypes are characterised for their peptide-binding motifs, although more information of this nature would contribute to a better interpretation of T cell-mediated immune responses. Here, we present the results of the characterisation of the functional properties of Mamu-B*037:01, an allotype commonly encountered in rhesus macaques of Indian and Chinese origin. Mamu-B*037:01 is seen to have a strong preference for acidic amino acids at the third residue, and for arginine, lysine, and tyrosine at the carboxyl terminus. This peptide-binding motif is not described in the human population.
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DOI: 10.1007/s00251-013-0734-5
Affiliations:
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Genetic analyses of the major histocompatibility class I region have revealed that these macaques display a substantial level of polymorphism at Mamu-A and Mamu-B loci, which have been subject to duplication. Only a few Mamu class I allotypes are characterised for their peptide-binding motifs, although more information of this nature would contribute to a better interpretation of T cell-mediated immune responses. Here, we present the results of the characterisation of the functional properties of Mamu-B*037:01, an allotype commonly encountered in rhesus macaques of Indian and Chinese origin. Mamu-B*037:01 is seen to have a strong preference for acidic amino acids at the third residue, and for arginine, lysine, and tyrosine at the carboxyl terminus. This peptide-binding motif is not described in the human population.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li><li>Utrecht (province)</li></region><settlement><li>Leyde</li><li>Utrecht</li></settlement><orgName><li>Université d'Utrecht</li></orgName></list><tree><country name="Pays-Bas"><noRegion><name sortKey="De Groot, Natasja G" sort="De Groot, Natasja G" uniqKey="De Groot N" first="Natasja G." last="De Groot">Natasja G. De Groot</name></noRegion><name sortKey="Bontrop, Ronald E" sort="Bontrop, Ronald E" uniqKey="Bontrop R" first="Ronald E." last="Bontrop">Ronald E. Bontrop</name><name sortKey="Bontrop, Ronald E" sort="Bontrop, Ronald E" uniqKey="Bontrop R" first="Ronald E." last="Bontrop">Ronald E. Bontrop</name><name sortKey="De Groot, Natasja G" sort="De Groot, Natasja G" uniqKey="De Groot N" first="Natasja G." last="De Groot">Natasja G. De Groot</name><name sortKey="De Ru, Arnoud H" sort="De Ru, Arnoud H" uniqKey="De Ru A" first="Arnoud H." last="De Ru">Arnoud H. De Ru</name><name sortKey="Doxiadis, Gaby G M" sort="Doxiadis, Gaby G M" uniqKey="Doxiadis G" first="Gaby G. M." last="Doxiadis">Gaby G. M. Doxiadis</name><name sortKey="Hassan, Chopie" sort="Hassan, Chopie" uniqKey="Hassan C" first="Chopie" last="Hassan">Chopie Hassan</name><name sortKey="Heijmans, Corrine M C" sort="Heijmans, Corrine M C" uniqKey="Heijmans C" first="Corrine M. C." last="Heijmans">Corrine M. C. Heijmans</name><name sortKey="Koning, Frits" sort="Koning, Frits" uniqKey="Koning F" first="Frits" last="Koning">Frits Koning</name><name sortKey="Otting, Nel" sort="Otting, Nel" uniqKey="Otting N" first="Nel" last="Otting">Nel Otting</name><name sortKey="Van Veelen, Peter A" sort="Van Veelen, Peter A" uniqKey="Van Veelen P" first="Peter A." last="Van Veelen">Peter A. 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